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Thymosin Beta-4

Also called Tβ4, RGN-352

InjectableEvidence BEvery day
Half-life
60hours
Typical vial
10mg
Research amounts
42–1260mg

per administration

Common schedule
Every day
Some human use

It has been used in people, but no trial has settled how much or how often.

The human evidence for Thymosin Beta-4 used the intravenous route. The draw worked out here assumes a subcutaneous injection, so the amount is not a direct read-across.

Quick start

Thymosin Beta-4 at a glance — the figures, plus how it's commonly run. Reference only, not medical advice.

Typical dose
42–1260 mg per administration
How often
Every day
Where
Intravenous (clinical setting)
Time to steady level
~12.5 days — about five half-lives
Storage
Dry vial kept cold and dark; a mixed vial in the fridge at 2–8 °C. Details

A research and community reference, not medical advice. Figures are descriptive, vary between sources, and are not a recommendation for use.

Work out your draw

These numbers are a starting point — change any of them.

Vial label

Copy this into your label printer.

Published research contexts for Thymosin Beta-4 describe 421260 mg per administration. Descriptive only, not a recommendation.

Thymosin β4 estimates vary widely; the TB-500 fragment page carries the same rough figure. Read as order-of-magnitude.

The full protein, distinct from the TB-500 fragment sold under that name. Human evidence is an intravenous safety study, so no subcutaneous schedule is established and no schedule table is shown; figures do not transfer to the fragment. The intravenous amounts studied (42–1260 mg) do not map onto a research vial, so the size shown is nominal.

Modelled level — every day

1× is the peak after a single dose.

Steady-state peak
4.13× single dose

Read off the modelled curve, not an even-interval formula

Time to steady state
12.5days

About five half-lives

Administrations
7/ week

Where these numbers come from

  • Ruff D et al., Ann N Y Acad Sci 2010;1194:223First-in-human intravenous thymosin β4 (RGN-352) at 42–1260 mg was assessed for safety in volunteers; no subcutaneous schedule was fixed.
  • Thymosin β4 preclinical repair literatureThe full protein's human data is limited to intravenous safety work; it is the parent molecule of the TB-500 fragment, and figures do not carry between the two.

Next steps

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