Growth hormone axis
Macimorelin
Also called Macrilen, Ghryvelin
per administration
A human trial worked out how much to take and how often, so a dosing schedule is shown.
Licensed as a medicine in the US and EU.
The human evidence for Macimorelin used the oral route. The draw worked out here assumes a subcutaneous injection, so the amount is not a direct read-across.
Quick start
Macimorelin at a glance — the figures, plus how it's commonly run. Reference only, not medical advice.
- Typical dose
- 35–35 mg per administration
- How often
- Every day
- Where
- Oral
- Time to steady level
- ~20 hours — about five half-lives
- Storage
- Dry vial kept cold and dark; a mixed vial in the fridge at 2–8 °C. Details
A research and community reference, not medical advice. Figures are descriptive, vary between sources, and are not a recommendation for use.
Work out your draw
These numbers are a starting point — change any of them.
Vial label
Copy this into your label printer.
Published research contexts for Macimorelin describe 35–35 mg per administration. Descriptive only, not a recommendation.
About 4 hours; a single oral dose, so the curve here is illustrative.
An oral peptidomimetic secretagogue given as a single 0.5 mg/kg dose (about 35 mg for a 70 kg adult) as a pituitary challenge, licensed in the US and EU; the 60 mg figure shown is the oral packet strength, not a vial, and no injected schedule is established, so no schedule table is shown.
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.02× single dose
- Time to steady state
- 20hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- Garcia JM et al., JCEM 2018;103:3083A single 0.5 mg/kg oral dose used as a growth-hormone secretagogue challenge, validated against the insulin-tolerance challenge for adult growth-hormone deficiency.