Growth hormone axis
MK-677
Also called Ibutamoren, Nutrobal, L-163191
per administration
A human trial worked out how much to take and how often, so a dosing schedule is shown.
The human evidence for MK-677 used the oral route. The draw worked out here assumes a subcutaneous injection, so the amount is not a direct read-across.
Quick start
MK-677 at a glance — the figures, plus how it's commonly run. Reference only, not medical advice.
- Typical dose
- 25–25 mg per administration
- How often
- Every day
- Where
- Oral
- Time to steady level
- ~30 hours — about five half-lives
- Storage
- Dry vial kept cold and dark; a mixed vial in the fridge at 2–8 °C. Details
A research and community reference, not medical advice. Figures are descriptive, vary between sources, and are not a recommendation for use.
Key properties
Molecular reference data.
- Formula
- C27H36N4O5S
- Mol. weight
- 528.7 Da
- CAS
- 159634-47-6
- PubChem CID
- 178024
External references
Work out your draw
These numbers are a starting point — change any of them.
Vial label
Copy this into your label printer.
Published research contexts for MK-677 describe 25–25 mg per administration. Descriptive only, not a recommendation.
About 4–6 hours; taken as a once-daily oral capsule.
An orally active growth-hormone secretagogue taken as a once-daily capsule; the 25 mg figure shown is a nominal oral capsule strength, not a vial. The human evidence is oral, so no injected schedule is shown.
What it can be combined with
How MK-677 is commonly discussed alongside other peptides and drugs.
Educational reference on commonly-discussed combinations, not medical advice. Combining compounds can change how each behaves — read this as a prompt to research, not a clearance.
- IpamorelinBoth act on the ghrelin / growth-hormone-secretagogue pathway, so running them together stacks the same mechanism rather than adding a new one.Use caution
- CJC-1295 (DAC)A GHRH analog and a growth-hormone secretagogue act on different steps of the same axis and are commonly discussed together.Commonly combined
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.07× single dose
- Time to steady state
- 30hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- Chapman IM et al., JCEM 1996;81:4249Daily oral MK-677 25 mg raised growth hormone and IGF-1 in healthy older volunteers over months.